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Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury

Mukhopadhyay, C and Dey, A and Bairy, I (2008) Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury. J Postgrad Med, 54 (1). pp. 35-36.

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Abstract

Glutaric aciduria type 1 (GA1) is an inborn error of organic acid metabolism, where the brain is the principal organ affected with exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A 2-year-old boy with GA1 and delayed developmental milestones had an acute neurological crisis leading to massive brain abscess with Citrobacter freundi infection, a rare cause of neonatal meningitis and often associated with brain abscess. Both 3-OHGA and C. freundii can damage the blood-brain barrier and can cause significant trauma which demands immediate and appropriate management. Encephalopathic manifestations of GA1 may consequently increase the risk of meningeal infection and it has not been previously documented.

Item Type: Article
Uncontrolled Keywords: Brain Abscess, Citrobactor freundii, glutaric aciduria type 1
Subjects: Medicine > KMC Manipal > Microbiology
Depositing User: KMC Manipal
Date Deposited: 13 Jun 2011 06:26
Last Modified: 22 Jul 2011 04:21
URI: http://eprints.manipal.edu/id/eprint/259

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