A Study of Biogenic amines and their metabolites in convulsions induced by maximum electric shock in Rats

Martis, Gladys and Karanth, KS and Rao, SN and Rao, A (1988) A Study of Biogenic amines and their metabolites in convulsions induced by maximum electric shock in Rats. Biochemical Archives, 4. pp. 453-458.

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Description: Catecholamines, serotonin, 5-hydroxy indole acetic acid(5-HIAA) and gamma amino butyric acid(GABA) were analyzed in the brains of male albino rats before and after convulsions induced by maximum electric shock (MES). Similarly, urinary total catecholamines, their metabolites 5-HIAA and cortisol were also estimated before and after these convulsions in the same group of rats. Variations in the levels of brain amines and GABA with time after treating with MES were also studied. There was a significant increse in the brain amines and GABA levels in maximum electric shock treated rats after 24 hours with no significant alteration in the 5-HIAA levels. There was also a marked increase in the levels of norepinephrine, dopamine and GABA in brain with a peak at 4 hours after MES whereas serotinin showed a peak at 2 hours after MES. The levels decreased gradually with time but were considerably higher than the control values even after 24 hours. However, in the urine there was a significant increase in the levels of total catecholamines with a significant decrease in the levels of 3-methoxy-4-hydroxyl phenyl glycol (MHPG) and cortisol. There is no significant change in the excretion of homoyallinic acid(HVA), vanillic mandelic acid(VMA) and 5-HIAA. Therefore an increased norepinephrine level in brain together with increased catetholamine excretion in urine relflects an increased turnover of norepinephrine after maximum electric shock induced convulsions in rats.

Item Type: Article
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Neurology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 20 Jan 2012 09:48
Last Modified: 20 Jan 2012 09:48
URI: http://eprints.manipal.edu/id/eprint/2590

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