Potent selective cytotoxic activity of kaempferia galangal L. rhizome against cancer cell cultures

Jagadish, PC and Raghu, Chandrasekhar H and Vinod Kumar, S and Latha, KP (2010) Potent selective cytotoxic activity of kaempferia galangal L. rhizome against cancer cell cultures. International Journal of Pharma and Bio Sciences, 1 (2). pp. 1-5.

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Abstract

Crude ethanol extract of the rhizome Kaempferia galanga L. and the successive extracts prepared with increasing polarity viz., petroleum ether, ethyl acetate and ethanol. The extracts and fractions were screened for cytotoxic activities by standard MTT and SRB assays against four cancerous viz., DU145, PA1, SW620, B16F10 and a normal Vero cell cultures. The successive ethyl acetate extract showed selective toxicity towards cancer cells and showed less toxicity towards normal cells. The successive petroleum ether fraction showed potent activity against human colorectal adenocarcinoma cells with CTC50 0.55 μg/ml and was comparatively non toxic towards normal Vero cell cultures.

Item Type: Article
Uncontrolled Keywords: Cytotoxicity, MTT assay, SRB assay, Kaemperia galanga
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 19 Jan 2012 09:29
Last Modified: 15 Jun 2012 10:13
URI: http://eprints.manipal.edu/id/eprint/2596

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