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Comparison of use of Antidiabetic Agents among Geriatric and Non-Geriatric Population.

*, Rajeshwari . S and Adhikari, Prabha M.R and Kotian, Shashidhar (2011) Comparison of use of Antidiabetic Agents among Geriatric and Non-Geriatric Population. Pharmacologyonline, 3. pp. 299-304.

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Abstract

In India, 20% of the elderly population has T2DM. The goals of treatment are the same for elderly and younger patients; however, treatment decisions are influenced by age, life expectancy, comorbid conditions, and severity of the vascular complications. Hence this study was conducted to compare and evaluate antidiabetic prescription pattern among geriatric and non-geriatric population. This cross-sectional study was conducted in a tertiary care teaching hospital. Patients of ≥60 years (geriatric), ≤ 60 years (non-geriatrics) with type 2 diabetes mellitus (DM) were identified and included in the study after obtaining written informed consent. Patient’s demographic data, age, sex, BMI and duration of diabetes were collected in a patient proforma. Details of antidiabetic agents prescribed were collected from the patients’ records. Data collected were analysed using x2 and students unpaired t test. A total of 477 diabetic patients were included for the study, 320 geriatric and 157 nongeriatrics. Mean age was 68.31±6.06 and 49.91±6.91 years respectively. Duration of DM was 11.38±8.90 and 6.52±5.71 years (z=0.001). Most commonly used oral antidiabetic agent was metformin (74.42%) either as monotherapy or in combination with other OAD agents, followed by sulfonylureas (69.18%). Among sulfonylureas glibenclamide (25.93% vs 23.56%) and glimepiride (23.75% vs 28.02%) were most commonly used by both the groups. Metformin was utilized more among nongeriatrics (p=0.03). There was no significant difference in the use of other antidiabetic drugs between the two groups. There was no significant difference in the distribution of patients on mono/combination antidiabetic therapy between the two groups. Geriatric diabetic patients utilized more of sulfonylureas and less of metformin compared to nongeriatric population.

Item Type: Article
Uncontrolled Keywords: Geriatric, nongeriatric, antidiabetic agents, sulfonylureas, metformin
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 16 Jan 2012 09:36
Last Modified: 07 Feb 2015 04:57
URI: http://eprints.manipal.edu/id/eprint/2602

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