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Pharmacological eveluation of alcoholic of stem bark of erythrina variegata for anxiolytic and anticonvulsant activity in mice

Pitchaiah, Gummalla and Viswanatha, GL and Srinath, R and Nandakumar, K (2008) Pharmacological eveluation of alcoholic of stem bark of erythrina variegata for anxiolytic and anticonvulsant activity in mice. Pharmacologyonline, 3. pp. 934-947.

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The objective of the present study was to evaluate the anxiolytic and anticonvulsant activity of alcoholic extract of stem bark of Erythrina variegata (ALEEV) in mice. Preliminary phytochemical studies of the extract revealed the presence of alkaloids, flavanoids, tannins and phenolic compounds, carbohydrates, proteins, saponins and triterpenoids. Acute oral toxicity was performed in albino mice as per OECD guidelines no.425 and it was found to be that the extract was safe till 2000 mg/kg. Anxiolytic activity of ALEEV was assessed using elevated plus- maze test (EPM), Open field test (OFT) and light-dark transition (LDT) models and anticonvulsant activity was assessed by using pentylene tetrazole (PTZ) induced convulsion models and maximal electroshock (MES) induced convulsion models. Pretreatment with ALEEV (400 and 800 mg/kg, po), increased the number of entries into the open arm and the time spent in the open arms in EPM; Increased total locomotion, time spent in central compartment, ambulation in OFT and Increased the latency to enter into the dark compartment, increased the time spent in the light compartment and increased number crossings between light and dark compartments in LDT indicating that ALEEV at these dose levels possess anxiolytic activity. Similarly in anticonvulsant models pretreatment with ALEEV (400 and 800 mg/kg, po) delayed the onset of clonic convulsions in PTZ induced convulsion model and duration of extensor phase in MES induced convulsions indicating that this extract possess anticonvulsant activity. These results suggested that ALEEV at doses of 400 and 800 mg/kg exhibited both anxiolytic and anticonvulsant activities but the effect was significant with high dose (800 mg/kg) of ALEEV.

Item Type: Article
Uncontrolled Keywords: Anxiolytic, Anticonvulsant, Erythrina variegate.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 19 Jan 2012 07:00
Last Modified: 19 Jan 2012 07:00

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