Protective effects of Moringa oleifera on experimentally induced gastric ulcers in rats

Das, Deepanjana and Dash, Devasrita and Mandal, Tatiyana and Kishore, Anup and Bairy, KL (2011) Protective effects of Moringa oleifera on experimentally induced gastric ulcers in rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2 (2). pp. 50-55. ISSN 0975-8585

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Abstract

To study the possible antiulcer effects of water extracts of Moringa oleifera in two animal models of ulcers. The water extract of leaves was prepared and tested for antiulcer activity at the dose level of 200mg and 400 mg/kg PO in pyloric ligation and ibuprofen induced gastric ulcer models. The effect of the extract was compared famotidine(3.6 mg/kg PO). The antiulcer effects of the drugs were assessed on the parameters such as number, size and index of ulcers and the volume, acidity and pH of gastric juice. The extract of Moringa oleifera and famotidine significantly (p<0.001) reduced ulcer index in the model employed. Both Moringa oleifera extract and famotidine reduced significantly (p<0.001) the free and total acidity of gastric juice. Moringa oleifera possesses gastric ulcer protective principles.

Item Type: Article
Uncontrolled Keywords: Moringa oleifera, gastric ulcer, famotidine, ibuprofen, antiulcer
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 19 Jan 2012 09:43
Last Modified: 19 Jan 2012 09:43
URI: http://eprints.manipal.edu/id/eprint/2617

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