Design and synthesis of certain mesoionic sydnonyl styrylketones as potential nonsteroidal antiinflammatory agents

Deshpande, Shreenivas Ramachandrarao and Pai, Karkala Vasantakumar and Pai, Ranganath Sridhar (2011) Design and synthesis of certain mesoionic sydnonyl styrylketones as potential nonsteroidal antiinflammatory agents. Arzneimittelforschung, 61 (3). pp. 180-185.

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Abstract

In an attempt to develop effective and safer analgesic anti-inflammatory agents, nine compounds belonging to 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methoxyphenyl) sydnones, containing the structural features of mesoionic sydnone and styrylketone, have been designed and synthesized by condensing 4-acetyl-3-(4-methoxyphenyl) sydnone with various substituted aryl aldehydes and characterized by spectral studies. They have been tested for analgesic activity by acetic acid induced writhing in mice and for anti-inflammatory activity by carrageenan induced rat paw edema at 100 mg/kg body weight p.o. The compounds containing furyl and chloro substituents showed highly significant analgesic effect, while those with dimethylamino, chloro and nitro substituents exhibited highly significant anti-inflammatory effect at the end of 3 h. The compounds that showed good analgesic and anti-inflammatory activities were evaluated for ulcerogenicity in rats to assess their gastric side effects at 100 mg/kg body weight p.o. They were found to be less ulcerogenic than the standard drug.

Item Type: Article
Uncontrolled Keywords: Analgesic effect, Anti-inflammatory effect, Mesoionic compounds, 3-(4-Methoxyphenyl)sydnone, Styrylketone Ulcerogenicity.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 21 Jan 2012 04:37
Last Modified: 21 Jan 2012 04:37
URI: http://eprints.manipal.edu/id/eprint/2633

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