Ameliorative effect of caffeic acid against inflammatory pain in rodents

Mehrotra, Anurag and Shanbhag, Ravindranath and Chamallamudi, Mallikarjuna Rao and Singh, Vijay Pal and Mudgal, Jayesh (2011) Ameliorative effect of caffeic acid against inflammatory pain in rodents. European Journal of Pharmacology, 666. pp. 80-86. ISSN 0014-2999

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The present study was designed to evaluate the antinociceptive profile of caffeic acid in mice and rats. Caffeic acid (5-100 mg/kg, p.o.), in a dose dependent manner inhibited acetic acid-induced writhing and late phase of formalin-induced pain in mice, with an ED(50) of 22.38 and 10.92 mg/kg, respectively. However, caffeic acid was ineffective in the hot plate and tail flick tests. Analgesic activity was also examined in carrageenan and lipopolysaccharide (LPS)-induced mechanical hyperalgesia in rats, where locally induced myeloperoxidase (MPO), malondialdehyde (MDA) and nitrite levels in foot pad were estimated by colorimetric assay. Oral administration of caffeic acid (200mg/kg, p.o.) showed analgesic activity similar to nimesulide (4 mg/kg, p.o.) and inhibited MPO, MDA and nitrite generation in the inflamed paw. Histological examination revealed reduction in neutrophil infiltration and protection of tissue damage by caffeic acid. These results suggest that caffeic acid exhibits peripheral analgesic effect in mice and rats and could be further examined for the treatment of chronic painful episodes.

Item Type: Article
Uncontrolled Keywords: Caffeic acid , Inflammatory pain . Myeloperoxidase , Malondialdehyde ,Nitrite
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 18 Jan 2012 06:10
Last Modified: 18 Jan 2012 06:10

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