Effect of Asparagus racemosus (Liliaceae) willd on dead space wound healing

Kodancha, Prabhath G and *, Satish Kumar MC and Rajput, Ravindrasingh and *, Vijayalakshmi and Udupa , AL and Gupta, Subir and *, Nkemcho Ojeh and *, Rathnakar UP and Benegal, Deepa and Benegal, Adarsh and *, Shubha HV and Rao, Sanjana and *, Nisarga S and Rao, Sahana (2011) Effect of Asparagus racemosus (Liliaceae) willd on dead space wound healing. Journal of Pharmacy Research, 4 (8). pp. 2772-2774. ISSN 0974-6943

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Objective of the study: Asparagus racemosus is a well known plant of medicinal value, with proven antioxidant, anti-inflammatory and immunomodulatory properties. Antioxidants are known to enhance wound healing. So the present study is aimed to investigate the wound healing profile of Asparagus racemosus on dead space wound model. Materials and methods: The aqueous extract of the roots of Asparagus racemosus was used to study the effect on wound healing in albino rats using a dead space wound model. The extract was administered orally in the dose of 200mg/kg or 400mg/kg for 10 days. The granulation tissue breaking strength and hydroxyproline, hexosamine and hexuronic acid content of granulation tissue were measured. Results & Discussion: The extract showed a significant increase in granulation tissue breaking strength, and a significant increase in hydroxyproline, hexosamine and hexuronic acid in granulation tissue. The observed effects in the test groups suggest the facilitatory effect of Asparagus racemosus on wound healing and the possible utility of this plant to enhance wound healing.

Item Type: Article
Uncontrolled Keywords: Asparagus racemosus, anti-inflammatory, wound healing, dead space wound.
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > MMMC Manipal > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 19 Jan 2012 06:00
Last Modified: 19 Jan 2012 06:00
URI: http://eprints.manipal.edu/id/eprint/2657

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