Joseph, Lebana J and Bhartiya, Uma S and Raut, Yogita S and Hawaldar, Rohini W and Nayak, Yogendra and Pawar, Yogita P and Jambhekar, Nirmala A and Rajan, MGR (2011) Radioprotective Effect of Ocimum sanctum and Amifostine on the Salivary Gland of Rats After Therapeutic Radioiodine Exposure. Cancer biotherapy & radiopharmaceuticals., 26 (6). pp. 737-743.

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Abstract

The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine (131I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) 131I exposure. Six months duration batch received 131I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before 131I exposure separately. Increased Technetium-99m-pertechnetate (99mTcO4 - ) uptake at 30 minutes post injection in salivary glands of only 131I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only 131I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to 131I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose 131I exposure.

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