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Synthesis and Evaluation of the Antiinflammatory Activity of N-[2-(3,5-Ditert- butyl-4-hydroxyphenyl)-4-oxothiazolidin- 3-yl]-nicotinamide

Kalia, Rajiv and Rao, Mallikarjuna C and Kutty, Gopalan N (2007) Synthesis and Evaluation of the Antiinflammatory Activity of N-[2-(3,5-Ditert- butyl-4-hydroxyphenyl)-4-oxothiazolidin- 3-yl]-nicotinamide. Arzneimittel-Forschung (Drug Research), 57 (9). pp. 616-622.

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Abstract

A new molecule incorporating nicotinoyl moiety, thiazolidin-4-one ring and 3,5-ditert- butyl-4-hydroxyphenyl roup (a potent antioxidant moiety) was synthesized and evaluated for anti-inflammatory activity in acute as well as chronic phase models of inflammation. The compound exhibited significant anti-inflammatory activity in three experimental models of inflammation, comparable to the positive control drug, ibuprofen (CAS 15687- 27-1). It is suggested that besides the hypolipidemicand anti-oxidant potential of the molecule, its anti-inflammatory action could possibly act as an additional mechanism of its hypothesized anti-atherosclerotic activity.

Item Type: Article
Uncontrolled Keywords: Anti-atherosclerotic drugs, Anti-inflammatory drugs, Anti-oxidants, N-[2(3,5-Di-tert-butyl-4- hydroxyphenyl)-4-oxo- thiazolidin- 3-yl]-nicotinamide, Nicotinic acid derivative, Thiazolidin-4-ones
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 23 Jan 2012 06:41
Last Modified: 07 Nov 2016 08:52
URI: http://eprints.manipal.edu/id/eprint/2671

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