Antioxidant and Hepatoprotective Activity of Pimenta Dioica Leaves Extract

Nayak, Y and Abhilash, D and Vijayanarayana, K and Fernandes, J (2008) Antioxidant and Hepatoprotective Activity of Pimenta Dioica Leaves Extract. Journal of Cell and Tissue Research, 8 (3). pp. 1571-1576.

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Abstract

The berries of Pimenta dioica (L)Merril (FamilyMyrtaceae) are commonly known as allspice in culinary. The natives of Kerala andMangalore use Allspice leaves as medicine for pain, arthritis, fever and stress. In all these pathological conditions oxidative stress is one of the causes, hence we tried extract the leaves for in vitro antioxidant activity. 20% yield of alcoholic extract obtained from the dry leaves showed total phenolic content (TPC) equivalent to 20 ± 1.63 mg/g of the dry leaves powder. The extract showed significant antioxidant activity by reducing power, DPPH radical scavenging and Lipid peroxidation assays. The antioxidant activity was proportional to the total phenolic content in the leaves. The high content of phenolic antioxidants in the extract urged us to screen for hepatoprotective activity in carbon tetrachloride (CCl4) intoxicated Wistar rats. The oral doses (250, 500, 750 mg/kg/day) showed statistically significant protection of liver when investigated by histopathological and biochemical parameters

Item Type: Article
Uncontrolled Keywords: Antioxidant, Hepatoprotection, Pimenta dioica leaves
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 23 Jan 2012 06:50
Last Modified: 04 Dec 2013 07:16
URI: http://eprints.manipal.edu/id/eprint/2675

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