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Antioxidant Analgesic and Anti-inflammatory Activities of Some Slected Heteroartyl Substituted Coumarins

Jayashree, BS and Arora, Sameer and Nayak, Yogendra (2008) Antioxidant Analgesic and Anti-inflammatory Activities of Some Slected Heteroartyl Substituted Coumarins. Pharmacologyonline 2 (3). pp. 404-410.

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Abstract

Significant amounts of Coumarins, with benzopyrone ring units, are frequently present in plants. Simple coumarins and analogues are a large class of compounds with a wide spectrum of biological activity. Several series of coumarin deriv tives were synthesized and five of the 5-(substituted phenyl)-1-phenyl- 2-pyrozoline-3″-yl) 6-halogen substituted coumarins were tested for in vivo analgesic and antiinflammatory studies. The compounds were selected on the basis of log P values and in vitro radical scavenging activities. Antiinflammatory activity was determined by carrageenan induced rat paw edema and analgesic activity was assessed by inhibition of hyperalgesia produced by carrageenan induced inflammation in the same rats by measuring the paw withdrawal latency. All compounds tested pharmacologically showed good analgesic and antiinflammatory activity in Wistar rats. The radical scavenging property may be one of the probable reasons for their analgesic and antiinflammatory activity.

Item Type: Article
Uncontrolled Keywords: Analgesic, Anti-inflammatory, Antioxidant, Coumarins
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 23 Jan 2012 09:07
Last Modified: 23 Jan 2012 09:07
URI: http://eprints.manipal.edu/id/eprint/2676

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