Newer carbostyril derivatives for antibacterial activity

Jayashree, BS and Jagarlamudi, Leela Rani and Nayak, Yogendra and Daroji, Vijaykumar (2009) Newer carbostyril derivatives for antibacterial activity. Pharmacologyonline , 1. pp. 322-327.

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Compounds having carbostyril (2-quinolones) moiety are associated with interesting biological activities. In the present study, we synthesized Schiff bases of 7-amino-4-methyl carbostyrils and their antibacterial activity was evaluated by agar diffusion method. The 7-amino-4-methyl carbostyrils were prepared by reacting m-phenylene diamine and β-ketoester by the Conard-Limpach synthesis. Schiff bases of 7-amino-4-methyl carbostyrils (1 to 10) were prepared by reacting 7-amino-4-methyl carbostyril with substituted aromatic aldehydes. The final test compounds were purified and characterized by the UV, IR, 1HNMR and Mass Spectral studies. They were evaluated for antibacterial activity. Four test compounds, such as 3, 6, 8 and 9 were active against Bacillus subtilis while Amoxicillin and Gentamycin were used as standards.

Item Type: Article
Uncontrolled Keywords: Carbostyrils; 2-Quinolones; Antibacterial; Schiff base
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 24 Jan 2012 06:15
Last Modified: 24 Jan 2012 06:15

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