Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system

Nayak, Usha Yogendra and Shavi, Gopal Venktesh and Nayak, Yogendra and Averineni, Ranjith Kumar and Mutalik, Srinivas and Reddy, Sreenivasa Meka and Gupta, Purshottam Das and Udupa, Nayanabhirama (2009) Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system. Journal of Controlled Release, 136. pp. 125-131. ISSN 0168-3659

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The purpose of the study was to develop pulsatile capsule dosage form of valsartan for controlled delivery. In the majority of individuals blood pressure rises in the early morning hours, which lead to serious cardiovascular complications. Formulations with constant/programmable delivery rates make it possible to deliver drug at definite time or controlled rate in chronopharmacokinetic studies. The prepared system contained swellable polymer (L-hydroxypropyl cellulose (L-HPC), xanthan gum, polyethylene oxide or sodium alginate) together with drug tablet and erodible tablet (L-HPC or guar gum) in a pre-coated capsule. Various formulation factors were investigated through series of tests, in vitro dissolution and ex vivo continuous dissolution–absorption studies. We found that the type, amount of polymers and erodible tablet influenced the drug release. The formulation containing 200 mg sodium alginate and erodible tablet (150 mg) containing 50% guar gum and 46% lactose showed 5–6 h lag time and 10±2.1% drug release in initial 6 h following rapid release (99±1.7% release in 12 h) of drug was observed. The continuous dissolution– absorption study conducted using everted rat intestinal segment indicated delay in absorption of drug. Thus this approach can provide a useful means for timed release of valsartan and may be helpful for patients with morning surge

Item Type: Article
Uncontrolled Keywords: Chronopharmacokinetic, Valsartan, Controlled delivery, Continuous dissolution–absorption
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 24 Jan 2012 09:48
Last Modified: 24 Jan 2012 09:48

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