Antidepressant activity of ethanolic extract of leaves of Ocimum sanctum in mice

Pemminati, Sudhakar and *, Gopalakrishna HN and Alva, Akshaya and Pai, MRSM and *, Seema Y and *, Vishnu Raj and Pillai, Durga (2010) Antidepressant activity of ethanolic extract of leaves of Ocimum sanctum in mice. Journal of Pharmacy Research, 3 (3). pp. 624-626. ISSN 0974-6943

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Abstract

Depression is a widespread psychiatric disorder affecting around 5% of the population. Furthermore, it is difficult to predict which patient will respond to any given treatment. In the traditional systems of medicine, many plants and formulations have been used to treat depression for thousands of years. Ocimum sanctum(OS), popularly known as Tulsi in Hindi and ‘Holy Basil’ in English is one of the sacred herbs for Hindus in the Indian subcontinent. It has a versatile role in traditional medicine. Therefore, the present study was undertaken to evaluate the antidepressant potential of acute and chronic administration of OS in forced swim test (FST) and tail suspension test (TST). Inbred adult male Swiss Albino mice weighing 25-30g were used in the study. Standard drug (imipramine) and test drug (OS) were suspended in 1% gum acacia. The vehicle (10ml/kg, p.o), imipramine (10mg/kg, p.o) and OS (1.75mg/kg, 4.25mg/kg, 8.5mg/kg, p.o. respectively) were administered 1hour prior to acute study. In chronic study, all drugs were given once a day for 10 days and the last dose was given 1hour before the experiment. Duration of immobility was noted in both the models. In our study, both imipramine and OS significantly reduced the duration of immobility in both experimental models as compared to the animals in the control group. The antidepressant activity of OS was comparable to that of standard drug imipramine. The results of the present study indicate the potential for use of OS as an adjuvant in the treatment of depression.

Item Type: Article
Uncontrolled Keywords: Ocimum sanctum, Forced swim test, Tail suspension test, Depression
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 21 Jan 2012 07:29
Last Modified: 21 Jan 2012 07:29
URI: http://eprints.manipal.edu/id/eprint/2703

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