Effect of tantu pashan on electrical and chemical induced seizures in mice

*, Sudhakar Pemminati and *, Gopalakrishna HN and *, Swati B and *, Shreyasi C and *, Raghavendra B and Pai, Preethi G and Pai , MRSM (2010) Effect of tantu pashan on electrical and chemical induced seizures in mice. Journal of Pharmacy Research, 3 (5). pp. 1178-1180. ISSN 0974-6943

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In traditional Indian system of medicine Tantu Pashan is being used for the treatment of epilepsy. Tantu Pashan is a mixture of Piper nigram, Piper chaba and Asbestos. But the scientific data about the efficacy of Tantu Pashan is not available. Hence, the present study was undertaken to evaluate efficacy of Tantu Pashan against maximal electrical shock (MES) and Pentylenetetrazole (PTZ) induced seizures in mice. Inbred albino mice of either sex weighing between 25 to 30 g were divided into five groups, containing eight animals in each. In acute study, drugs / vehicle were administered one hour before the experiment. In chronic study, drugs /vehicle were administered once a day for 21days and the experiment was conducted one hour after the last dose. Tantu pashan on acute administration in MES induced seizures; only at the highest dose (160mg/kg) significantly reduced the duration of hind limb tonic extension, while in PTZ induced seizures, it did not alter the duration of seizures to any significant level when compared with control group. On chronic administration, the test drug significantly reduced the duration of tonic hind limb extension and also the clonus phase in MES induced seizures. But, in PTZ induced seizures, neither it reduced the duration of clonic convulsion nor protected the animals from death. Results indicates that Tantu Pashan has protective effect against MES, but not against PTZ induced seizures.

Item Type: Article
Uncontrolled Keywords: Tantu Pashan, maximal electro-shock, epilepsy, pentylenetetrazole
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 21 Jan 2012 07:29
Last Modified: 21 Jan 2012 07:29
URI: http://eprints.manipal.edu/id/eprint/2716

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