Antibacterial activity of newly synthesised pyridinyl coumarin derivatives

Jayashree, BS and Porwal, Brajesh and Nayak, Yogendra and Vijay Kumar, D (2010) Antibacterial activity of newly synthesised pyridinyl coumarin derivatives. Pharmacologyonline, 1. pp. 190-199.

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Synthesis of Pyridinyl coumarins were achieved by treating 3- bromoacetyl coumarins with pyridine, esters of nicotinic and isonicotinic acids in anhydrous toluene as solvent system. Initially 15 derivatives of coumarinyl pyridinium bromides (1.a – o) were synthesised and purified in good yields. Three of the 3-coumarinoyl pyridinium bromide salts (1.m – o) reacted with different chalcones in glacial acetic acid to obtain 7 derivatives of pyridinyl coumarins (2.a – g). Further, 3-bromoacetyl coumarins treated with quinoline in dry toluene to obtain coumarinoyl quinolinium salts (3.a – c). Out of the 22 test compound synthesized, 8 test compounds exhibited minimum inhibitory concentration on par with the standard antibacterial such as Amoxicillin and Gentamycin. Test compounds showing promising antibacterial activity were showing Log P values well within the range to express the optimum biological activity.

Item Type: Article
Uncontrolled Keywords: Pyridinyl coumarin, 3-Bromoacetylcoumarin, Antibacterial
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 27 Jan 2012 10:22
Last Modified: 27 Jan 2012 10:22

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