Anxiolytic and Anticonvulsant Activity of Aqueous Extract of Stem Bark of Erythrina variegata in Rodents

Pitchaiah, G and Viswanatha, GL and Srinath, R and Nandakumar, K and Dayabaran, D and Florance, EJ (2010) Anxiolytic and Anticonvulsant Activity of Aqueous Extract of Stem Bark of Erythrina variegata in Rodents. International Journal of PharmTech Research, 2 (1). pp. 40-48.

[img] PDF
134._International_Journal_of_PharmTech_Research,_Jan-Mar_2010,_2(1),_40-48.PDF - Published Version
Restricted to Registered users only

Download (195kB) | Request a copy

Abstract

Erythrina variegata and some other species of genus Erythrina are known to act on central nervous system. In India, Erythrina variegata is the species generally used by the traditional practioners of south India for the treatment of mental illness. The anxiolytic effect of aqueous extract (100, 200 and 400 mg/kg) was evaluated by using elevated plus-maze(EPM) model, light-dark transition (LDT) model and open field test (OFT), while Pentylene tetrazole (PTZ),Maximal electroshock (MES) induced convulsions models were used to assess anticonvulsant activity in male swiss albino mice. Pretreatment with aqueous extract and estimation of GABA in rat brain tissues also performed to study the effect of aqueous extract (100, 200 mg/kg) on GABA levels of brain. Aqueous extract showed significant anxiolytic and anticonvulsant activity and also showed significant modulation of GABA levels in cerebellum and also in whole brain other than cerebellum.

Item Type: Article
Uncontrolled Keywords: Erythrina variegata; Anxiolytic; Anticonvulsant; GABA
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 30 Jan 2012 04:16
Last Modified: 30 Jan 2012 04:16
URI: http://eprints.manipal.edu/id/eprint/2734

Actions (login required)

View Item View Item