Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives

Isloor, Arun M and Kalluraya, Balakrishna and Pai, Sridhar K (2010) Synthesis, characterization and biological activities of some new benzo[b]thiophene derivatives. European Journal of Medicinal Chemistry, 45. pp. 825-830. ISSN 0223-5234

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Abstract

Benzo[b]thiophene molecules are found to be important tools in synthetic medicinal chemistry. They are of current interest due to their wide spectrum of pharmacological properties. In view of the biological activities of benzo[b]thiophene containing molecules, in this present research work, we propose the synthesis of some new benzo[b]thiophene derivatives such as thiadiazoles, oxadiazoles, pyrazolin & diaryl pyrazoles starting from 3-chlorobenzo[b]thiophene-2-carboxyl chloride. These newly synthesized compounds were characterized by elemental analyses, I.R, NMR and Mass spectral studies. Some of the selected compounds were screened for their antibacterial, antifungal and anti-inflammatory studies. Many of the molecules were found to be potent.

Item Type: Article
Uncontrolled Keywords: Benzo[b]thiophene; Anti-inflammatory activity; Antibacterial & antifungal activity.
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 30 Jan 2012 06:23
Last Modified: 30 Jan 2012 06:23
URI: http://eprints.manipal.edu/id/eprint/2737

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