Panda, SS and Chowdary, PVR and Jayashree, BS (2009) Synthesis Antiinflammatory and Antibacterial Activity of Novel Indolyl-isoxazoles. Indian Journal of Pharmaceutical Sciences., 71 (6). pp. 684-687.
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Abstract
Chalcones were synthesized by reacting indole-3-aldehyde, prepared by Vilsemeir Haack reaction with 4-substituted acetophenone in ethanolic KOH solution.These chalcones were immediately reacted with hydroxylamine hydrochloride in presence of glacial acetic acid as reagent to obtain the corresponding isoxazole derivatives.The synthesized heterocycles were characterized on the basis of physical chemical tests and spectroscopic data.These compounds were tested for the acute antiinflammatory activity antibacterial activity using carrageenan-induced rat paw edema method and cup-plate method, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Antibacterial activity, antiinflammatory activity, indolyl-isoxazoles |
| Subjects: | Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry |
| Depositing User: | KMC Manipal |
| Date Deposited: | 30 Jan 2012 07:19 |
| Last Modified: | 30 Jan 2012 07:19 |
| URI: | http://eprints.manipal.edu/id/eprint/2752 |
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