Comparing Hypoglycemic activity of nopales (Opuntia species) with conventional anti diabetic in diabetic reat model

Sindhu, D and Praveena, MDPS and Chogtu, Bharti and Bairy, KL (2011) Comparing Hypoglycemic activity of nopales (Opuntia species) with conventional anti diabetic in diabetic reat model. Pharmacologyonline , 2. pp. 172-177.

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Abstract

The objective of this study was to evaluate the blood glucose lowering activity of Nopales in streptozotocin induced rats and to compare it with conventional antidiabetic glibenclamide. Diabetes was induced in rats by injecting Streptozotocin. After two weeks , rats were divided in five groups and administered - nopales 1mg/kg, nopales5mg/kg, glibenclamide 5mg/kg, nopales + glibenclamide , normal saline for 20 days. Blood glucose levels were taken at baseline and then on 7th and 20th day . There was significant decrease in blood glucose levels on 20th day in all the groups. However, nopales 5mg/kg (p<0.01)and nopales+ glibenclamide(p<0.01) showed a greater decrease in blood glucose leves as compared to nopales 1mg/kg(p<0.05) and glibenclamide 5mg/kg(p<0.05). To conclude Nopales 5mg/kg shows a decrease in blood glucose levels and this decrease is comparable to conventional antidiabetics.

Item Type: Article
Uncontrolled Keywords: Nopales, antidiabetic, diabetic rat model
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 31 Jan 2012 04:43
Last Modified: 31 Jan 2012 04:43
URI: http://eprints.manipal.edu/id/eprint/2777

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