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Pulmonary Nocardiosis due to Nocardia farcinica in a Renal Transplant Recipient

Gowrinath, K and Baig, Waqas Wahid and Prabhu, Ravindra A and Chawla, Kiran and Bairy, Indira (2009) Pulmonary Nocardiosis due to Nocardia farcinica in a Renal Transplant Recipient. Indian J Chest Dis Allied Sci, 51. pp. 237-239.

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Abstract

Nocardia farcinica is an infrequent cause of nocardiosis among the renal transplant recipients and it has not been reported so far from India. We report a case of pulmonary nocardiosis due to N. farcinica in a 32-year-old woman with hypothyroidism and post-renal transplant status, currently on immunosuppressive therapy (prednisolone, azathioprine and tacrolimus). The N. farcinica isolate was susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), linezolid, imipenem, gentamicin but resistant to ceftriaxone, ciprofloxacin, tobramycin, erythromycin, amoxycillin-clavulanic acid and tetracycline. Treatment with TMP-SMZ and linezolid resulted in marked clinico-radiological improvement but after two weeks both of the drugs had to be stopped due to severe pancytopenia as adverse effect of their use. Currently, the patient is on imipenem and remains stable after four weeks of treatment. In N. farcinica infections, multi antibiotic resistance and toxicity of some specific drugs enhances the risk of therapeutic failure in renal transplant recipients.

Item Type: Article
Uncontrolled Keywords: Nocardiosis, Nocardia farcinica, Renal transplantation, Chemotherapy, Trimethoprim-Sulfamethoxazole, Linezolid
Subjects: Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Nephrology
Medicine > KMC Manipal > Pulmonary Medicine
Depositing User: KMC Manipal
Date Deposited: 15 Jun 2011 06:13
Last Modified: 09 Apr 2016 11:53
URI: http://eprints.manipal.edu/id/eprint/278

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