Studies on Brahma Rasayana in Male Swiss Albino Mice: Chromosomal Aberrations and Sperm Abnormalities

Guruprasad, KP and Mascarenhas, Roshan and Gopinath, PM and Satyamoorthy, K (2010) Studies on Brahma Rasayana in Male Swiss Albino Mice: Chromosomal Aberrations and Sperm Abnormalities. Journal of Ayurveda and Integrative Medicine, 1 (1). pp. 40-44.

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Abstract

Ayurveda, the Indian holistic healthcare system encompasses traditional medicines with a principle of creating harmony and maintaining balance within the natural rhythms of the body. Rasayana is one of the branches of Ayurveda frequently used as rejuvenant therapy to overcome many discomforts and prevent diseases. It has been reported that rasayanas have immunomodulatory, antioxidant and antitumor functions. However, the genotoxic potential of many rasayanas remains to be evaluated. The present study was undertaken to assess the role of Brahma rasayana(BR) on genotoxicity in vivo in a mouse test system. The older mice (9 months) were orally fed with rasayana for 8 weeks. The treated groups showed no signs of dose-dependent toxicity at the dosage levels tested. The body weight loss/gain and feed consumption were unaffected at tested doses. Furthermore, sperm abnormalities and chromosomal aberrations were insignificant in the treatment group when compared to controls. However, there was a marginal increase in sperm count in the BR treated animals. These findings clearly indicate that there are no observed adverse genotoxic effects elicited by BR in experimental animals such as mice

Item Type: Article
Uncontrolled Keywords: Aging, Brahma Rasayana, Chromosomal Aberrations, Genotoxicity, Sperm Abnormalities
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 31 Jan 2012 06:32
Last Modified: 31 Jan 2012 06:32
URI: http://eprints.manipal.edu/id/eprint/2793

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