In-vitro Anthelmintic and Antimicrobial Activities of Stem Bark of Eugenia jambolana Lam

Sudeep, HV and Ramachandra, YL and Ganapathy, Sujan PS and Rai, Padmalatha S (2009) In-vitro Anthelmintic and Antimicrobial Activities of Stem Bark of Eugenia jambolana Lam. International Journal of Biomedical and Pharmaceutical Sciences, 3 (1). pp. 46-49.

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Abstract

n order to scientifically appraise some of the folkloric uses of Eugenia jambolana Lam. (Myrtaceae), the present study was undertaken to examine the anthelmintic and antimicrobial properties of stem bark extracts. The anthelmintic activity of ethyl acetate and methanol extracts was tested on tape worm (Moniezia expansa) and hook worm (Gaigeria pachyscelis) at two concentrations, 100 and 200 mg/ml. Time taken for the inhibition of motility and the death were noted and compared with the standard drug, Piperazine citrate at 15 mg/ml. The plant extracts significantly paralysed the worms followed by death, which was comparable with that of standard. Further, these extracts along with petroleum ether extract were tested for their activity against 24 clinically isolated microbial strains, including identified strains, using agar well diffusion method. The methanol extracts showed highest activity followed by ethyl acetate, while the petroleum ether extract showed the lowest activity at 100 mg/ml. The inhibitory effect of extracts was compared with standard antibiotic Ciprofloxacin and antifungal miconazole. This study supports the folk claim. _____________________________________________________________________________________________________________

Item Type: Article
Uncontrolled Keywords: Gastrointestinal, Pathogen, plant extract, Worm
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 01 Feb 2012 04:36
Last Modified: 08 Apr 2013 09:45
URI: http://eprints.manipal.edu/id/eprint/2802

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