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Evaluation of Wound Healing Activity of Butea monosperma Lam. Extracts on rats

Gavimath, CC and Sudeep, HV and Ganapathy, Sujan PS and Rai, Padmalatha S and Ramachandra, YL (2009) Evaluation of Wound Healing Activity of Butea monosperma Lam. Extracts on rats. Pharmacologyonline, 2. pp. 203-216.

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Abstract

Butea monosperma Lam. (Fabaceae) is a medium sized deciduous tree known for its antimicrobial, antiulcerogenic, anti-inflammatory properties etc. The present study was aimed for wound healing potential of ethanol and aqueous extract of B. monosperma (stem bark) using three types of wound models in rats as incision wound, excision wound and dead space wound. The results were obtained in terms of wound contraction, epithelialization time, tensile strength, hydroxyproline content and granuloma weight. Enhanced wound contraction and decreased epithelialization time were observed in extract-treated animals in excision wound model. The tensile strength of the incision wound was significantly increased in comparison to control group. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in treated animals compared with control.

Item Type: Article
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 01 Feb 2012 04:51
Last Modified: 01 Feb 2012 04:51
URI: http://eprints.manipal.edu/id/eprint/2806

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