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Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing the haloperidol- induced catalepsy in mice

*, Albina Arjuman and Nair, Vinod and *, HN Gopala Krishna and *, M Nandini (2007) Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing the haloperidol- induced catalepsy in mice. Indian Journal of Pharmacoljune, 39 (3). pp. 151-154.

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Abstract

Objective : To evaluate the possible role of the antioxidant activity of the polyherbal formulation, NR-ANX-C and its individual components in reversing haloperidol-induced catalepsy in Swiss albino mice. Materials and Methods : Catalepsy was induced with haloperidol (1 mg/kg i.p) in 13 groups of male albino mice (n = 6 / group). Three groups received NR-ANX-C (10, 25, 50 mg/kg), three groups received Withaniasomnifera (1.7, 4.25, 8.5 mg/kg), another three groups Ocimum sanctum (1.7, 4.25, 8.5 mg/kg), three other groups Camellia sinensis (3.4, 8.5, 17 mg/kg) and one group received the vehicle (1% Gum acacia) orally, 30 minutes prior to haloperidol administration, for a duration of seven days. Animals were sacrificed on the seventh day and superoxide dismutase (SOD) activity was estimated in the brain. Results : A significant (P < 0.01) reduction in the cataleptic scores was observed in all the drug-treated groups as compared to the control, with maximum reduction in the NR-ANX-C 25 mg/kg group. Similarly, a reduction in SOD activity was observed in the NR-ANX-C-, O. sanctum- and the W. somnifera-treated groups. An increase in SOD activity was observed in the C. sinensis-treated groups. Conclusion : With the exception of C. sinensis, the antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration.

Item Type: Article
Uncontrolled Keywords: Camellia sinensis, catalepsy, haloperidol, Ocimum sanctum, oxidative stress, Withaniasomnifera
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 03 Feb 2012 05:57
Last Modified: 03 Feb 2012 05:57
URI: http://eprints.manipal.edu/id/eprint/2891

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