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A preliminary study on antidepressant activity of NR-ANX-C (a polyherbal product) in mice

*, Gopalakrishna HN and shastry, Rajeshwari and *, Sudhakar Pemminati and shenoy, Ashok K and *, Alwar MC and *, Rathnakar UP and Pai, MRSM (2010) A preliminary study on antidepressant activity of NR-ANX-C (a polyherbal product) in mice. Journal of Pharmacy Research , 3 (3). pp. 550-553.

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Abstract

Depression is one of the common psychiatric disorders. Though the modern medicine provides large number of antidepressants, each of them has one or the other draw backs. Thus the search for new antidepressants with minimum or without side effects is deemed important. NR-ANX-C, a polyherbal product composed of Withania somnifera, Ocimum sanctam, Camellia sinensis, Triphala and Shilajit have been shown to have antistressor, antianxiety and anticataleptic activity. With this back ground, the present study was undertaken to evaluate the antidepressant activity of this polyherbal preparation by employing two experimental models, forced swim test and tail suspension test in mice. Imipramine (5.0 & 10.0 mg/kg) was used as the standard drug. NR-ANX-C (5, 10, & 20 mg/kg) was given orally. Antidepressant effect was studied both on acute and chronic administration. NR-ANX-C significantly reduced the duration of immobility on single and repeated administration. These findings were comparable to that produced by standard drug, imipramine. Our study suggests that, NR-ANX-C has antidepressant like activity in mice.

Item Type: Article
Uncontrolled Keywords: NR-ANX-C, Antidepressant, Imipramine.
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 03 Feb 2012 05:57
Last Modified: 03 Feb 2012 05:57
URI: http://eprints.manipal.edu/id/eprint/2895

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