Photobiomodulatory effects of He-Ne laser on excision wounds

Prabhu, Vijendra and Rao, Satish BS and Kumar, Pramod and Rao, Lakshmi and Mahato, Krishna K (2011) Photobiomodulatory effects of He-Ne laser on excision wounds. Proc. of SPIE, 7887. pp. 1-9. ISSN 1605-7422

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Presently, great importance has been given to Low Level Laser Therapy (LLLT) with the intent of promoting wound healing process. The present study was aimed to investigate the promotive effect of LLLT on full thickness excision wounds in Swiss albino mice using optical fiber probe based light device. Circular wounds of diameter 15 mm were illuminated with single exposure of various laser doses 1, 2, 3, 4, 6, 8 and 10 J/cm2 along with appropriate controls. Further, an optimal dose of 2 J/cm2 was applied to excision wounds at different post-wounding treatment schedules (0, 24 h and 48 h) to explicate the relations between treatment schedule and its tissue regeneration potential. Wound area, mean wound healing time along with hydroxyproline and glucosamine levels from wound ground tissue was assessed to evaluate the resultant photobiostimulatory outcome. Histological analysis was performed on day 10 of post-wounding. A significant increase in hydroxyproline (P< 0.001) and glucosamine levels (P< 0.01) were observed in 2 J/cm2 irradiation group, which was also substantiated by histological findings. In conclusion, the present study demonstrated that the immediate irradiation of 2 J/cm2 dose following wounding hasten the healing process compared to the unilluminated control.

Item Type: Article
Uncontrolled Keywords: Excision wound, mean healing time, treatment schedule, tissue regeneration potential, wound contraction.
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Plastic Surgery
Depositing User: KMC Manipal
Date Deposited: 08 Feb 2012 10:38
Last Modified: 08 Feb 2012 10:38

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