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Nasal Insulin Gel as an Alternate to Parenteral Insulin: Formulation, Preclinical, and Clinical Studies

D’Souza, Reshma and Mutalik, Srinivas and Venkatesh, Madhavacharya and Vidyasagar, Sudha and Udupa, Nayanabhirama (2005) Nasal Insulin Gel as an Alternate to Parenteral Insulin: Formulation, Preclinical, and Clinical Studies. AAPS PharmSciTech, 6 (2). E184-E189.

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Abstract

The objective of the present study was to formulate insulin gel for intranasal administration and to evaluate with respect to in vitro release studies and hypoglycemic activity in animal model and healthy human volunteers. The insulin gel was formulated using the combination of carbopol and hydroxypropyl methylcellulose as gelling agent. The in vivo efficacy of insulin gel administered intranasally was assessed by measuring the blood glucose levels and serum insulin levels at specified time intervals in rats and humans. The use of bioadhesive nasal gel containing insulin not only promoted the prolonged contact between the drug and the absorptive sites in the nasal cavity but also facilitated direct absorption of medicament through the nasal mucosa. Absorption of the drug through the nasal mucosa was high in the first 0.5 to 1.5 hours of the study with a sharp decline in blood sugar and rise in insulin values corresponding to that decline in blood sugar. This study further demonstrates that administration of insulin intranasally in gel form is a pleasant and painless alternative to injectable insulin.

Item Type: Article
Uncontrolled Keywords: nasal, diabetes mellitus, insulin, gel, carbopol, preclinical, clinical
Subjects: Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 17 Jun 2011 06:27
Last Modified: 17 Jun 2011 06:27
URI: http://eprints.manipal.edu/id/eprint/296

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