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5-Aminosalicylic acid reverses endosulfan-induced testicular toxicity in male rats

Jaiswal, Amardeep and Parihar, Vipan Kumar and Kumara, Sudheer M and Rao, Manjula SD and Krishnanand, BR and Shanbhag, Ravindranath and Unnikrishnan, MK (2005) 5-Aminosalicylic acid reverses endosulfan-induced testicular toxicity in male rats. Mutation Research, 585. pp. 50-59.

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Abstract

Pre-treatment with 5-aminosalicylic acid (5-ASA) significantly reduced sperm-shape abnormalities in endosulfan-treated rats. The number of abnormal sperm in the epididymiswas markedly increased by endosulfan treatment but pre-treatment with 5-ASA kept these values close to normal. Treatment with 5-ASA at a dose of 25 mg/kg bw was more effective in reducing sperm-shape abnormality and sperm count than at a dose of 50 mg/kg bw. Endosulfan significantly increased the level of lactate dehydrogenase (LDH) in rats but a marked decrease was observed upon pre-treatment with 25 mg/kg bw 5-ASA. Changes in plasma testosterone levels were not significantly correlated with 5-ASA pre-treatment but histopathological analysis of seminiferous tubules and Leydig cells showed significant protection from endosulfan-induced tissue damage such as necrosis. The population of Sertoli cells increased and the lumen of the seminiferous tubules contained a greater number of spermatids. There was a corresponding increase in the number of Leydig cells. A curative study with 5-ASA showed a similar protection from endosulfan-induced toxicity and cellular damage, but the extent of protection was significantly lower.

Item Type: Article
Uncontrolled Keywords: Endosulfan, Genotoxicity, Testis, 5-Aminosalicylic acid (5-ASA), Sperm-shape abnormality, Sperm count, Lactate dehydrogenase (LDH), Testosterone, Histopathology
Subjects: Medicine > KMC Manipal > Pathology
Pharmacy > MCOPS Manipal > Pharmacology
Medicine > KMC Manipal > Physiology
Depositing User: KMC Manipal
Date Deposited: 17 Jun 2011 06:49
Last Modified: 21 Mar 2015 09:37
URI: http://eprints.manipal.edu/id/eprint/297

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