Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis

Sharma, Mohit and Bairy, Indira and Pai, Keerthilatha M and Satyamoorthy, K and Prasad, Shailendra and Berkovitz, Barry and Radhakrishnan, Raghu (2011) Salivary IL-6 levels in oral leukoplakia with dysplasia and its clinical relevance to tobacco habits and periodontitis. Clinical Oral Investigations, 15 (5). pp. 705-714.

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The development of oral cancer proceeds through discrete molecular changes that are acquired from loss of genomic integrity after continued exposure to environmental risk factors. It is preceded in the majority of cases by clinically evident oral potentially malignant disorders, the most common of which is leukoplakia. Early detection of these oral lesions by screening methods using suitable markers is critical as it mirrors molecular alterations, long before cancer phenotypes are manifested. Assessment of salivary interleukin-6 (IL-6) as a marker of malignant progression was undertaken in patients with leukoplakia having coexisting periodontitis (n=20), periodontitis patients without leukoplakia (n=20), and healthy controls (n=20) by competitive enzyme-linked immunosorbent assay. Results showed elevation of IL-6 levels in leukoplakia with coexisting periodontitis and in periodontitis patients when compared to healthy control (P<0.001). Within the leukoplakia group, IL-6 level was found to be increased with increase in the severity of dysplasia. The use of tobacco was seen to play a significant role in the elevation of salivary IL-6.The importance of IL-6 as a specific marker for leukoplakia with dysplasia and the role of tobacco as an independent risk factor has been highlighted.

Item Type: Article
Uncontrolled Keywords: IL-6 . NF-κB . Leukoplakia . Epithelial dysplasia . Periodontitis . Oral cancer . Tobacco
Subjects: Dentistry > MCODS Manipal > Oral Medicine and Radiology
Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Microbiology
Depositing User: KMC Manipal
Date Deposited: 16 Feb 2012 09:49
Last Modified: 22 Oct 2016 15:29

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