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Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure

Shirwaikar, Annie and Issac, Deepti and Malini, S (2004) Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure. Journal of Ethnopharmacology, 90. pp. 81-86.

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Abstract

The ethanol extract of the entire plant of Aerva lanatawas studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300 mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300 mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin.

Item Type: Article
Uncontrolled Keywords: Aerva lanata; Cisplatin; Gentamicin; Nephrotoxicity; Nephroprotection; Acute renal failure
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 15 Jul 2011 06:15
Last Modified: 15 Jul 2011 06:15
URI: http://eprints.manipal.edu/id/eprint/299

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