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Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat

Shirwaikar, Annie and Khan, Saleemulla and Malini, S (2003) Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat. Journal of Ethnopharmacology, 89. pp. 245-250.

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Abstract

Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750 mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3–5 were orally treated with Raloxifen (5.4 mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750 mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect.

Item Type: Article
Uncontrolled Keywords: Osteoporosis, Cissus quadrangularis, Bone fragility, Bone mineral density, Biomechanical strength, Tartrate resistant acid phosphatase (TRAP), Alkaline phosphatase (ALP)
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 15 Jul 2011 06:48
Last Modified: 16 Mar 2012 04:20
URI: http://eprints.manipal.edu/id/eprint/303

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