Effect of Punica granatum peel extract on learning and memory in rats

Adiga, Shalini and Trivedi, Prabhav and Ravichandra, V and Deb, Debashree and Mehta, Forum (2010) Effect of Punica granatum peel extract on learning and memory in rats. Asian Pacific Journal of Tropical Medicine, 3 (9). pp. 687-690.

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Objective:To evaluate potential memory enhancing effect of Punica granatum peel extract on rats. Methods:Healthy adult male albino rats of Wistar strain were used. Each group of 6 rats were administered either distilled water or 50 mg/kg of extract or 100 mg/kg of extract for 15 days and subjected to passive avoidance test or T-maze test. In the next phase rats were administered distilled water or 100 mg/kg of extract for 15 days and the rats were given injection diazepam before subjecting them to the tests. Results:The overall performance was better in test groups compared to control groups. Among the test groups, 100 mg/kg rats performed better than 50 mg/kg. The effect on spatial learning parameters like mean number of alternations and mean percentage bias was more marked compared to retention testing parameters like latency. 100 mg/kg Punica extract treated group also improved performance of diazepam treated rats. Conclusions:There is a definite trend of memory improvement by Punica granatum peel with effects being more marked on spatial learning tendency and long term memory than on retention capacity.

Item Type: Article
Uncontrolled Keywords: Punica granatum peel; Learning; Memory; Oxidative stress; Diazepam; Amnesia
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 18 Feb 2012 06:22
Last Modified: 18 Feb 2012 06:22
URI: http://eprints.manipal.edu/id/eprint/3059

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