CAG repeat length polymorphism in the androgen receptor gene and breast cancer risk: data on Indian women and survey from the world

Rajender, Singh and Francis, Amirtharaj and Pooja, Singh and Krupakar, Nallala and Surekha, D and Reddy, Gopal and Rao, Raghunatha D and Rao, Lakshmi and Ramachandra, S and Vishnupriya, S and Ramalingam, K and Satyamoorthy, K and Thangaraj, Kumarasamy (2011) CAG repeat length polymorphism in the androgen receptor gene and breast cancer risk: data on Indian women and survey from the world. Breast Cancer Res Treat, 127 (3). pp. 751-760.

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Abstract

We analyzed the length of the CAG repeats of the androgen receptor gene in Indian women with breast cancer, and compared the data with that of other populations across the world in an attempt to find a potential pattern of association. The study was undertaken on 1,408 individuals comprising 747 breast cancer patients and 661 control individuals recruited from three southern states of India: Andhra Pradesh, Tamil Nadu, and Karnataka. The comparison revealed no difference in mean length of the repeat between cases and controls in any of the three groups or in the analysis of pooled data. No significant difference between pre- and post-menopausal cases in any of the three groups or in the analysis of pooled data was observed. Most of the studies to date support either positive association (longer repeats—increased disease risk) or no association, and only 2 out of 20 studies reported negative association (inverse correlation between repeat length and disease risk). Comparison of these data with those from other populations revealed several interesting facts. Particularly notable is that repeat length shows association with breast cancer risk in a population-specific manner with most of the studies on American and Canadian women showing positive association, whereas those on Australian and Israeli women showing no association. Only one study had been conducted on other populations including Asians/ South Asians; this estricted us from finding any patterns of association in these populations.

Item Type: Article
Uncontrolled Keywords: Breast cancer . Androgen receptor . CAG repeat polymorphism
Subjects: Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 18 Feb 2012 07:09
Last Modified: 18 Feb 2012 07:09
URI: http://eprints.manipal.edu/id/eprint/3076

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