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Antidiabetic effect through islet cell protection in streptozotocin diabetes: A preliminary assessment of two thiazolidin-4-ones in Swiss albino mice

Kishore, Anoop and Nampurath, Gopalan Kutty and Mathew, Suma P and Zachariaha, Robby T and Potu, Bhagath Kumar and Rao, Muddanna S and Valiathan, Manna (2009) Antidiabetic effect through islet cell protection in streptozotocin diabetes: A preliminary assessment of two thiazolidin-4-ones in Swiss albino mice. Chemico-Biological Interactions, 177. pp. 242-246.

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Abstract

This study was undertaken on the basis of several reports in the literature that pancreatic beta cells are capable of replication/regeneration and also being afforded protection against damage induced by streptozotocin. Nicotinamide was reported to give protection against streptozotocin-induced damage in rats. In the present study, two thiazolidine-4-ones with nicotinamide substitution were administered to Swiss albino mice with streptozotocin diabetes for 15 days. Concurrently, one group received nicotinic acid. Both the test compounds reversed the hyperglycaemia diabetic mice. Damage to pancreatic isletswas also reduced in these groups compared to diabetic control and nicotinic acid treated groups. Since these compounds have been earlier found have antioxidant activity, one of the possible mechanisms of action could be by reducing oxidative stress in pancreas. Further, possibly by releasing nicotinamide in vivo, the molecules could have contributed to the NAD pool in pancreas and afforded protection. It is concluded that the test compounds have potential to be developed for multiple beneficial action in conditions like metabolic syndrome.

Item Type: Article
Uncontrolled Keywords: Thiazolidin-4-ones, Hypoglycaemic, Hypolipidaemic, Nicotinic acid
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > KMC Manipal > Pathology
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 18 Jun 2011 06:44
Last Modified: 18 Jun 2011 06:44
URI: http://eprints.manipal.edu/id/eprint/313

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