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Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury

Anniea, S and Rajagopala, PL and Malini, S (2005) Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury. Phytomedicine, 12. pp. 555-560.

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Abstract

The ethanol extract of the roots of Cassia auriculata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced renal injury in male albino rats. In the cisplatin model, the extract at doses of 300 and 600 mg/kg body wt. reduced elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model, the ethanol extract at a dose of 600 mg/kg body wt. reduced blood urea and serum creatinine effectively in both the curative and the preventive regimen. The extract had a marked nitric oxide freeradical- scavenging effect. The findings suggest that the probable mechanism of nephroprotection by C. auriculata against cisplatin- and gentamicin-induced renal injury could be due to its antioxidant and free-radical-scavenging property.

Item Type: Article
Uncontrolled Keywords: Cassia auriculata, Cisplatin, Gentamicin, Nephrotoxicity, Nephroprotection
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 18 Jun 2011 09:43
Last Modified: 18 Jun 2011 09:43
URI: http://eprints.manipal.edu/id/eprint/319

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