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Modulatory effects of vitamin c on genotoxic effect of endosulfan in developing albino rats

Rao, Manjula SD and Benjamin, Susan and Bairy, Laxminarayana K (2006) Modulatory effects of vitamin c on genotoxic effect of endosulfan in developing albino rats. Iranian journal of pharmacology &therapeutics, 5 (2). pp. 113-116.

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Abstract

The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were stu-died by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group),Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic effect was stu-died by bone marrow micronuclei assay. There was an increase in micronuclei in polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) and a decrease in PCE and P/N ra-tio in endosulfan treated rats. The effect was similar to the standard mutagen cyclophosphamide. In rats treated with vitamin C and endosulfan, there was an increase in PCE and P/N ratio and decrease in micronuclei in PCE and NCE. This could be due to the antimutagenic effect of vita-min C.

Item Type: Article
Uncontrolled Keywords: Endosulfan, Cyclophosphamide, Vitamin C, Bone marrow micronuclei, PCE, NCE
Subjects: Medicine > KMC Manipal > Pharmacology
Medicine > KMC Manipal > Physiology
Depositing User: KMC Manipal
Date Deposited: 23 Feb 2012 06:03
Last Modified: 21 Mar 2015 09:31
URI: http://eprints.manipal.edu/id/eprint/3246

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