The effect of carbamazepine on sperm counts in Wistar rats - reflecting upon its mitogenic potential

Shetty, Akhila J and Narayana, K and Bairy, KL and Bhat, Parvathi and D'Souza, Urban (2007) The effect of carbamazepine on sperm counts in Wistar rats - reflecting upon its mitogenic potential. Reproductive Biology, 7 (2). pp. 177-181.

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Abstract

The present study was aimed to investigate the effects of carbamazepine, an antiepileptic drug, on sperm count in rats. Male Wistar rats were treated with carbamazepine at doses of 9, 18, and 36 mg/kg for five consecutive days. Following the last exposure, on days 14 and 35, spermatozoa were collected from epididymis and counted. On day 14, carbamazepine treatment decreased the sperm number in a dose dependent pattern. On day 35, 9 mg/kg and 36 mg/kg of carbamazepine increased the sperm number in comparison with untreated rats. The results of the study suggest that carbamazepine is a germ cell mitogen.

Item Type: Article
Uncontrolled Keywords: carbamazepine , mitogenic factor , germ cells
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 01 Mar 2012 04:44
Last Modified: 01 Mar 2012 04:44
URI: http://eprints.manipal.edu/id/eprint/3254

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