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Evaluation of homonia riparia lour. For antiurolithiatic Activity in albino rats

Prasad, KVSRG and Abraham, R and Bharathi, K and Srinivasan, KK (1997) Evaluation of homonia riparia lour. For antiurolithiatic Activity in albino rats. International Journal of Pharmacognosy, 35 (4). pp. 278-283.

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Abstract

Ethanol extract of the roots of Homonia riparia was tested for its antiurolithiatic activity against calcium oxalate and magnesium ammonium phosphate stones in male albino rats. Calcium oxalate stones were induced by feeding 3% glycolic acid along with normal feed and magnesium ammonium phosphate stones were induced by implantation of zinc discs in the urinary bladder. The ethanol extract of H. riparia (2 g/kg/day, orally) was found to be effective in reducing deposition of calcium in the kidney of both prophylactic and curative group animals. The extract did not show any significant effect on the activity of the liver enzyme glycolic acid oxidase and on the deposition of oxalate in the kidney. The extract was found to be effective in reducing the formation and also in dissolving the pre-formed magnesium ammonium phosphate type of stones.

Item Type: Article
Uncontrolled Keywords: Antiurolithiatic activity, calcium oxalate, glycolic acid oxidase activity, Homonia riparia, magnesium ammonium phosphate, urinary electrolytes.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 21 Jun 2011 10:28
Last Modified: 05 Oct 2013 07:04
URI: http://eprints.manipal.edu/id/eprint/332

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