Evaluation of two uterotonic medications for the management of the third stage of labor

*, P. Kushtagi and *, L.M. Verghese (2006) Evaluation of two uterotonic medications for the management of the third stage of labor. International Journal of Gynecology and Obstetrics, 94 (1). pp. 47-48.

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Abstract

No consensus exists among clinicians concerning the best way to prevent postpartum hemorrhage. Scope of 125 mcg of carboprost tromethamine given intramuscularly with intravenous methyl ergometrine was evaluated in 215 parturients in randomized study. Both groups were with regard to age, parity and gestational age and were comparable regarding the labor outcomes in terms of occurrence of tears in the birth canal and neonatal birth weight. The mean duration of third stage was significantly less in the group receiving methyl ergometrine (3.9 vs. 4.3 min; p=0.038). the measured blood loss was also less in methyl ergometrine receiving group. No difference was found in hemoglobin estimates before and after delivery among either of the groups. There was transient hypertension seen in 1% cases receiving methyl ergometrine and among carboprost group there was trend towards increasing blood loss as duration of labor increased. It was concluded that methyl ergometrine continues to be a better oxytocic available for the prevention of postpartum hemorrhage.

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