Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract inWistar rats

Amuthan, Arul and Chogtu, Bharti and Bairy, KL and Sudhakar, * and Prakash, Mungli (2012) Evaluation of diuretic activity of Amaranthus spinosus Linn. aqueous extract inWistar rats. Journal of Ethnopharmacology, 140 (2). pp. 424-427. ISSN 0378-8741

[img] PDF
Evaluation_of_diuretic_activity_of_Amaranthus_spinosus_Linn._aqueous_extract_in_Wistar_rats.pdf - Published Version
Restricted to Registered users only

Download (657kB) | Request a copy


Ethnopharmacological relevance: Traditional Siddha medicine literature claims that the Amaranthus spinosus Linn. (family: Amaranthaceae) whole plant possesses diuretic property. Aim of the study: To evaluate the diuretic potential of Amaranthus spinosus aqueous extract (ASAE) in rats. Material and methods: Different concentrations of ASAE (200, 500, 1000, 1500 mg/kg), thiazide (10 mg/kg) and vehicle were orally administered to rats (n = 6 animals per group) and their urine output was collected after 24 h. Volume, pH, Na+, K+ and Cl− concentrations of urine were estimated. Results: ASAE produced increase in Na+, K+, Cl− excretion, caused alkalinization of urine, showed strong saluretic activity and carbonic anhydrase inhibition activity. These effects were observed predominantly at 500 mg/kg dose and there was no dose–response relationship. Conclusion: Our study strongly suggests that the Amaranthus spinosus is acting as a thiazide like diuretic with carbonic anhydrase inhibitory activity which restates the claim as diuretic herb in Siddha medicine.

Item Type: Article
Uncontrolled Keywords: Siddha medicine Amaranthus spinosus Diuretic Urine volume Urine pH Electrolytes
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 17 Mar 2012 05:03
Last Modified: 17 Mar 2012 05:03
URI: http://eprints.manipal.edu/id/eprint/3478

Actions (login required)

View Item View Item