Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of Uterine Cervix

Kushtagi, Pralhad and Sarkar , Subrato (2000) Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of Uterine Cervix. Journal Of Obstetrics and Gynaecology of India, 50 (3). pp. 81-83.

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Human Papilloma virus (HPV) assay in 53 formalin fixed paraffin embedded biopsy specimens of squamous cell carcinoma of uterine cervix was carried out by in situ deoxyribonucleic acid (DNA) hybridization using Digene HPV tissues hybridization kit (Vira Type in situ HPV Probe Set: catalogue Number 42060100. Digene Diagnostics Inc., USA). Seven types of HPV were used as DNA probes. Eleven of the samples (20.8 per cent) were positive for HPV. Types 16 and 18 present in 10 samples (18.9 per cent) types 6 and 11 in 3 ( 5.7 per cent) and types 31, 33 and 38 in 1 (1.9 per cent). Three samples had multiple infection. Follow up outcome as related to the disease status in 11 HPV positive cases when compared to the matching (age, parity, stage, and degree of differentiation) controls was higher (27.3 per cent to 9 per cent) at 6 months, but showed no difference thereafter throughout the follow-up till 36 months of planned radiation therapy. It is concluded that the low incidence of HPV in carcinoma cervix could be due to regional variations in occurance and that no opinion can be drawn regarding the influence of HPV genotype on clinical outcome.

Item Type: Article
Uncontrolled Keywords: Human Papilloma virus; Carcinoma Cervix
Subjects: Medicine > KMC Mangalore > Obstetrics & Gynaecology
Depositing User: KMCMLR User
Date Deposited: 17 Mar 2012 05:00
Last Modified: 17 Mar 2012 05:00

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