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Quadruple Therapy for Initial Eradication of Helicobacter Pylori in Peptic Ulcer: Comparison with Triple Therapy

Pai, CG and Thomas, CP and Rao, S and Ramnarayan, K and Biswas, A (2003) Quadruple Therapy for Initial Eradication of Helicobacter Pylori in Peptic Ulcer: Comparison with Triple Therapy. Indian J Gastroenterol, 22 (3). pp. 85-87.

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Abstract

Quadruple therapy appears to be more effective than standard triple therapy in the management of patients with Helicobacter pylori infection who harbor drug-resistant organisms.No data are available on the relative efficacies of triple and quadruple drug regimens from India. METHODS: Consecutive patients with peptic ulcer and H.pylori infection were randomized to receive lansoprazole 30 mg twice daily along with either amoxycillin (500 mg four times daily) and clarithromycin (500 mg twice a day) Group A), or tri-potassium dicitrato bismuthate (120 mg four times daily), metronidazole (400 mg thrice daily)and tetracycline (500 mg 4 times daily) (Group B) for 10 days. Presence of H. pylori infection was looked for using an in-house urease test and histology before starting treatment, and 30 days after completion of treatment.RESULTS: Twenty-nine of 35 patients in Group A and 24 of 33 in Group B had eradication of infection (82.8% and 72.7% by intention-to-treat analysis, and 87.9% and 85.7% by per protocol analysis, respectively; p = ns). Side-effects occurred in 4 12%) and 5 (18%) patients in Groups A and B, respectively (p = ns); discontinuation of drugs was required in two patients in group B.CONCLUSIONS: Quadruple therapy for initial treatment of H. pylori infection does not offer any advantage over standard triple therapy in Indian patients.

Item Type: Article
Uncontrolled Keywords: Antimicrobial therpy,Duodenal Ulcer,Gastric Ulcer.
Subjects: Medicine > MMMC Manipal > Physiology
Medicine > KMC Manipal > Medicine
Depositing User: KMC Manipal
Date Deposited: 23 Jun 2011 04:09
Last Modified: 03 Oct 2013 11:07
URI: http://eprints.manipal.edu/id/eprint/357

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