In Vivo Study for Anti-inflammatory Activity of Bauhinia variegata L.Leaves

Saha, Santanu and Subrahmanyam, EVS and Chandrashekar, KS and Shastry, Shashidhara C (2011) In Vivo Study for Anti-inflammatory Activity of Bauhinia variegata L.Leaves. Pharmaceutical Crops, 2. pp. 70-73.

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Bauhinia variegata L. (Rakta kanchan) has been traditionally used in India for treatment of a variety of inflammatory conditions, skin diseases, stomatitis, leprosy and for wound healing. Using mostly in vitro models, a number of published reports confirmed the anti-inflammatory potential of the leaves, bark and roots of this tree. The isolation of a bioactive triterpene saponin from the leaves and a flavonol glycoside from the roots has also been reported. In the present study, we have evaluated the anti-inflammatory activity of the leaf extract of B. variegata, using three in vivo animal models: the carrageenan induced rat paw edema, cotton pellets induced granuloma formation, and adjuvant induced arthritis in rat. Both the ethanol extract and the petroleum ether fraction obtained from this extract demonstrated activity in all the three bioassays. The activity was found to be more pronounced in the petroleum ether fraction. These bioactivities compared favorably with diclofenac sodium, which was used as positive control, and confirms the traditional usefulness of this plant for the treatment of both acute and chronic inflammatory conditions.

Item Type: Article
Uncontrolled Keywords: Adjuvant-induced arthritis, Anti-inflammatory activity, Bauhinia variegata, Fabaceae, Cotton pellet granuloma, Ethanol extract, Petroleum ether fraction
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 19 Mar 2012 04:09
Last Modified: 10 Dec 2015 09:15

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