A pilot study of the antioxidant effect of curcumin in tropical pancreatitis

Durgaprasad, S and Pai, Ganesh C and Kumar, Vasanth and Alvres, Jose Filipe and Sanjeeva, Sanjeeva and Namitha, * (2005) A pilot study of the antioxidant effect of curcumin in tropical pancreatitis. Indian J Med Res, 122. pp. 315-318.

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Background & objectives: Oxidative stress occurs in association with painful exacerbations of chronic pancreatitis and antioxidant supplementation appears to benefit this condition. Curcumin, the active constituent of turmeric, is known to exhibit antioxidant activity. This pilot study was therefore undertaken to evaluate the effect of oral curcumin with piperine on the pain, and the markers of oxidative stress in patients with tropical pancreatitis (TP).Methods: Twenty consecutive patients with tropical pancreatitis were randomised to receive 500mg of curcumin with 5mg of piperine, or placebo for 6 wk, and the effects on the pattern of pain, and on red blood cell levels of malonyldialdehyde (MDA) and glutathione (GSH) were assessed. Results: There was a significant reduction in the erythrocyte MDA levels following curcumin therapy compared with placebo; with a significant increase in GSH levels. There was no corresponding improvement in pain. Interpretation & conclusion: Oral curcumin with piperine reversed lipid peroxidation in patients with tropical pancreatitis. Further studies with large sample are needed to define its effect on the pain and other manifestations of tropical pancreatitis.

Item Type: Article
Uncontrolled Keywords: Antioxidants - chronic pancreatitis - curcumin -glutathione - lipid peroxidation - malonyldialdehyde - oxidant stress - treatment
Subjects: Medicine > KMC Manipal > Gastroenterology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 02 Apr 2012 05:07
Last Modified: 02 Apr 2012 05:07
URI: http://eprints.manipal.edu/id/eprint/3677

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