High dose radiation induced meningioma

Shenoy, SN and Munish, KG and Raja, A (2004) High dose radiation induced meningioma. British Journal of Neurosurgery, 18 (6). pp. 617-621. ISSN ISSN 0268-8697 print/ISSN 1360-046X

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Radiation therapy has played an important integral part in the management of various intracranial tumours. However, radiation has been implicated in the development of intracranial tumours. We describe three cases of radiation-induced meningiomas following high dose cranial irradiation. All these patients developed tumours within the previous radiation field and satisfied the criteria used for the definition of radiation-induced neoplasm. The interval between the irradiation and the onset of meningioma was significantly less in the younger patient. All the cases had several unique features of radiationinduced meningioma including features of atypical meningioma. Two patients developed multiple site meningiomas and one patient developed early recurrence of the tumour. This report confirms that patients exposed to cranial irradiation are at lifelong risk of developing radiation-induced tumours such as meningiomas. Hence these patients require long-term clinical and radiological surveillance to detect occurrence as early as possible.

Item Type: Article
Uncontrolled Keywords: Meningioma, radiation induced tumour, atypical meningioma, radiotherapy, oncogenesis
Subjects: Medicine > KMC Manipal > Neuro Surgery
Depositing User: KMC Manipal
Date Deposited: 24 Jun 2011 05:16
Last Modified: 24 Jun 2011 05:16
URI: http://eprints.manipal.edu/id/eprint/368

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