Alternative markers of glycemic status in diabetes mellitus

Hegde, Anupama and Shenoy, Ramya and D'MeIlo, Prajwal and *, Smitha A and *, Tintu A and Manjrekar, Poornima (2010) Alternative markers of glycemic status in diabetes mellitus. Biomedical Research , 21 (3). pp. 252-256.

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Abstract

Monitoring people with diabetes by repeatedly estimating blood glucose and glycosylated hemoglobin levels is invasive which becomes appalling and expensive over time Potential of saliva as a diagnostic tool could be exploited in this regard. 26 diabetes patients were com - pared with 21 age matched non-diabetic heakhy controk for Fasting plasma glucose (FPG). salfv ary glucose (SG), saliv ary pH (SpH), Oral heakh slams and markers of oxidative stress in saliva namely Thiobarbiturie Acid Reactive substance (TEARS) or Malondiafdehyde (MBA) and Total antioxidant activity (AOA). S high FPG (p=o.005) along with high salivary ADA (p < 0.0001) levels, markedly lesser SpH and MBA were found in the di- abetic group. Changes in SG levels between the groups were of no consequence FPG showed positive correlation to SG (r = 0.410) and even better correlation wkh salivary MBA (r = 0.562) only in diabetes. Since SG levels did not differ betwan the two groups, the study concludes that conventional marker like FPG is a better indicator of glycemic slams. Lower MBA seen in saliva of diabetic group may be probably due to the exceptionally high ADA activity seen in these people

Item Type: Article
Uncontrolled Keywords: Fasting Plasma Glucose, Diabetes, MDA, TOA, Saliva, Salivary glucose, Salivary pH
Subjects: Dentistry > MCODS Mangalore > Public Health Dentistry
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 05 Apr 2012 07:21
Last Modified: 05 Apr 2012 07:21
URI: http://eprints.manipal.edu/id/eprint/3708

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