Evidence for oxidant stress in chronic pancreatitis

Pai, Ganesh C and Sreejayan, * and Rao, MN (1999) Evidence for oxidant stress in chronic pancreatitis. Indian Journal of Gastroenterology, 18 (4). pp. 156-157.

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Background: Oxidant stress leading to lipid peroxidation is reported to be the common link in the pathogenesis of chronic pancreatitis irrespective of etiology. Aim: To look for evidence of lipid peroxidation in duodenal juice in patients with chronic pancreatitis. Methods: 19 patients with chronic pancreatitis (14 tropical, 5 alcoholic) and 19 age- and sex-matched subjects with abdominal pain without any cause were studied. Contents were aspirated from the second part of the duodenum during gastroduodenoscopy. Malonyl dialdehyde (MDA) levels were measured in duodenal juice by the thiobarbituric acid method. Results: MDA levels were higher in patients than in the control group (mean [SD] 42.6 [17.0] vs 29.2 [11.7] nmol/mL; p < 0.05). On linear and multiple regression analysis, none of the disease factors correlated with duodenal juice MDA levels. Conclusions: Lipid peroxidation products are increased in patients with chronic tropical and alcoholic pancreatitis.

Item Type: Article
Uncontrolled Keywords: Duodenal juice, lipid peroxidation
Subjects: Medicine > KMC Manipal > Gastroenterology
Depositing User: KMC Manipal
Date Deposited: 04 Apr 2012 07:31
Last Modified: 04 Apr 2012 07:31
URI: http://eprints.manipal.edu/id/eprint/3710

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